Analysis of the reasons and solutions for the weight difference of the tablet press

Reasons and solutions for the weight loss of the tablet press:

1 The particle size distribution is uneven, and the particle flow rate is different when the tablet is pressed, resulting in unevenness of the particles filled into the middle die hole. The particles should be mixed or sieved to remove too much fine powder.

2 When the fine powder adheres to the punch and causes the slamming, the difference in the weight of the sheet can be made larger. At this time, the undershooting rotation is not flexible, and it should be checked in time, the die is removed, and the undercut and the middle die hole are cleaned.

3 The flowability of the particles is not good, and the amount of particles flowing into the middle die hole is often small, causing the difference in the weight of the film to be too large and exceeding the limit. It should be regranulated or added with a suitable glidant such as micronized silica gel to improve the fluidity of the particles.

4 particle layering. The particles are layered to reduce the difference in particle size.

5 smaller tablets use larger particles. Choose the right size of the particles.

6 The hopper is blocked, and this phenomenon often occurs in drugs with strong viscosity or moisture permeability. The hopper should be dredged, the tableting environment should be dry, and the glidant should be added as appropriate.

7 The material storage amount in the material varies greatly. Control is within 50%.

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