Best Price Hot Selling Trilostat CAS 13647-35-3

Model NO.: 13647-35-3
CAS: 13647-35-3
Appearance: White Powder
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 12345677
Model NO.: 13647-35-3
CAS: 13647-35-3
Appearance: White Powder
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 12345677
Details
Product name: Trilostane,Vetoryl,Desopan,Modrastane,Modrenal,Modrefen
CAS No.: 13647-35-3
EINECS:237-133-0
Assay: 99%
Molecular formula: C20H27NO3
Molecular weight: 329.43
Appearance: White crystalline powder 
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.



Description
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase,
 which plays a role in adrenal steroid biosynthesis. Investigators believe 
that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 
3β-HSD, but not 
3βHSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular
 production oin LNCaPFGC prostate cancer cells and inhibiting cortisol biosynthesis in the human 
adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

Best Price Hot Selling Trilostat CAS 13647-35-3


Applications
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5, 4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

Side effect: Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.



COA
Product name
Trilostane
CAS
CAS No.

13647-35-3

Outer Packing

1KG

Production date

Nov.03th,2016

Shelf life

Nov.02th,2019

Standard adopted


Enterprise Standard

Items of analysis

Specification

Results


Identification


Positive


Confirm


Appearance


White to pale white solid


white solid


Melting point


257°C to 270°C


261°C -267°C


Heavy metals


No more than 20ppm


10ppm


Loss on drying


Not more than 0.5%


0.15%


Residue on ignition


Not more than 0.1%


0.020%


Solubility


soluble in dimethyl sulfoxide;soluble in pyridine;slightly soluble in ethanol;slightly soluble in water


conforms


Assay


Not less than 99.0%


99.6%


Specific Rotation


+137-139°


137.5°


ated impurities


not more than 1.0%


0.35%


HPLC purity


not less than 99.0%


99.6%


Solvent Residues


Ethanol<5000ppm


1000ppm

Conclusion

Qualified


Our advantage
1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

  Details
Product name: Trilostane,Vetoryl,Desopan,Modrastane,Modrenal,Modrefen
CAS No.: 13647-35-3
EINECS:237-133-0
Assay: 99%
Molecular formula: C20H27NO3
Molecular weight: 329.43
Appearance: White crystalline powder 
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.



Description
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase,
 which plays a role in adrenal steroid biosynthesis. Investigators believe 
that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 
3β-HSD, but not 
3βHSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular
 production oin LNCaPFGC prostate cancer cells and inhibiting cortisol biosynthesis in the human 
adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

Best Price Hot Selling Trilostat CAS 13647-35-3


Applications
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5, 4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

Side effect: Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.



COA
Product name
Trilostane
CAS
CAS No.

13647-35-3

Outer Packing

1KG

Production date

Nov.03th,2016

Shelf life

Nov.02th,2019

Standard adopted


Enterprise Standard

Items of analysis

Specification

Results


Identification


Positive


Confirm


Appearance


White to pale white solid


white solid


Melting point


257°C to 270°C


261°C -267°C


Heavy metals


No more than 20ppm


10ppm


Loss on drying


Not more than 0.5%


0.15%


Residue on ignition


Not more than 0.1%


0.020%


Solubility


soluble in dimethyl sulfoxide;soluble in pyridine;slightly soluble in ethanol;slightly soluble in water


conforms


Assay


Not less than 99.0%


99.6%


Specific Rotation


+137-139°


137.5°


ated impurities


not more than 1.0%


0.35%


HPLC purity


not less than 99.0%


99.6%


Solvent Residues


Ethanol<5000ppm


1000ppm

Conclusion

Qualified


Our advantage
1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

 

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