Recently, under the support of the National Natural Science Foundation, Professor Xi Xinyan and Wang Xin of the Fourth Military Medical University Xijing Hospital confirmed that genistein (GEN) can inhibit the growth of ovarian cancer xenografts in nude mice. This research provides new ideas for improving the clinical efficacy of ovarian cancer.
Ovarian cancer is a common malignant tumor in gynecology. The heavy metal chemotherapeutic drug cisplatin (DDP) is one of the effective drugs for the treatment of ovarian cancer, but its toxic and side effects are obvious, and many patients can not tolerate it, which limits its application. GEN is widely present in plants, and in vitro and in vivo studies have shown that GEN has a significant inhibitory effect on breast cancer, prostate cancer and colon cancer cells.
When investigating the effect of phytoestrogens GEN and DDP in the treatment of human ovarian cancer xenografts in nude mice, the researchers established 20 human ovarian cancer xenograft models, which were randomly divided into 4 groups. Control studies have found that GEN has a significant inhibitory effect on human ovarian cancer xenografts in nude mice, and has synergistic effects with DDP; GEN acts on tumor cells, inhibits tumor cell proliferation and tumor area neovascular growth, blocks tumors Blood supply is related.
Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae,which reaches up to 1 m tall and native to India, South America, China and the East Indies. Highly branched, yellow to orange, cylindrical, aromatic rhizomes are found.Turmeric, a yellow root, imparts color and flavor to food and has been used as a color and/or spice for centuries, that is produced by grinding the rhizomes of the perennial herb, Curcuma longa. The colourings responsible for the bright yellow hue of turmeric are the pigments curcumin, demethoxycurcumin and bisdemethoxycurcumin.
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