New sensor: detecting disease through breathing or urine

Release date: 2009-08-03

Future sensors can determine whether they have breast, lung, diabetes or asthma from their breathing – researchers at the University of Missouri are developing a new device that analyzes respiratory and urine samples to indicate that the body has A volatile marker of a disease. These volatile labels are an alkane hydrocarbon, acetone, nitric oxide, and the like.

According to Fan Xudong, a researcher at the University's Christopher S. Bond Life Science Center, "a few traces of certain gas molecules in the exhaled breath or urine can tell us if abnormal conditions have occurred in the body. Measuring these volatile markers may be a non-invasive diagnosis. A new approach to disease that allows the test to take no blood or biopsy. Currently, in addition to some of the biomarkers that have been discovered, a large number of potential volatile markers are still being studied."

The sensing device is called an opto-fluidic ring resonator (OFRR) and is an optical gas sensor. It consists of a glass tube for guiding the lining polymer through which the gas or vapor flows and an annular chamber for detecting molecules flowing through the glass tube. After gas or steam enters the unit, the molecules in the vapor separate and react with the polymer liner. Thousands of halo rings are generated around the gas or vapor sample. The more halo around the sample, the more light and gas or steam The stronger the interaction. Steam molecules can be detected by these repeated interactions.

In addition to its applications in the medical field, optical gas sensors have a wide range of applications in industrial, military, environmental and homeland security applications. For example it can be used to detect explosives on the battlefield. However, the existing gas sensing technology equipment is very large, more than 100 pounds, and it is difficult to use in the field. Fan Xudong said: "We hope to design a gas sensor that is ultra-sensitive, specific and capable of responding to certain molecules, has on-site chemical analysis capabilities, and is small, portable, low-power, and reusable. He said, "If the gas sensor is portable, then a single soldier can quickly determine which area is dangerous."

It is understood that Fan Xudong graduated from Peking University and now works in addition to the Christopher S. Bond Life Science Center at the University of Missouri, USA. He is also an assistant professor at the School of Agriculture, Food and Natural Resources at the University of Missouri School of Engineering. His research is supported by the American Natural Science Foundation. His research results are published in authoritative journals in international optics such as Optics Letters, Optics Express and Analytical Chemistry. Shanghai Medical Device Industry Association

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